Sustainability database


Prof David Leys

Professor of Structural Biology

The research in our group mainly uses x-ray crystallography and a range of other techniques to address how macromolecular structure determines function. We focus on several aspects: how do proteins interact with other macromolecules (RNA, DNA or other proteins) or their substrates?  How do enzymes work, particularly those for which mechanistic insight is lacking? Protein structures also form the basis of protein engineering and for structure-based drug design. We are studying proteins of both medical and biotechnological interest (ie biofuel production) to provide for the much needed structural insight into these enzymes.

Sustainability enthusiast?: 



Rapid Evolution of Enzymes

The use of biocatalysts in the manufacture of chemicals presents significant advantages in terms of enhanced reaction selectivity, reduced cost of raw materials, lower energy costs, safety and importantly sustainability.



Direct biological conversion of solar energy to volatile hydrocarbon fuels by engineered cyanobacteria.


Centre of Excellence for Biocatalysis, Biotransformations and Biocatalytic Manufacture

Welcome to the Centre of Excellence for Biocatalysis, Biotransformations and Biocatalytic Manufacture (CoEBio3) website. The CoEBio3 is the UK’s new organisation designed to provide a world-class scientific environment in which the necessary research and development can be carried out to create new biocatalyst-based processes to meet the changing needs of industry in the next 10-20 years.

Biocatalysis, Biology, Biochemistry


Manchester Institute of Biotechnology

The Manchester Interdisciplinary Biocentre (renamed the Manchester Institute of Biotechnology in Autumn 2012) was completed in 2006 and represented the first university-based, purpose-built interdisciplinary research institute of its kind in the UK.

Biology, Innovation, Biotechnology


Biophysics and Structural Biology

The Biophysics and Structural Biology research group brings together researchers interested in understanding biology at the molecular level, linking structure with function. Research in the group spans the kingdoms of life investigating the molecular basis of virus, plant, microbial, animal and human biology. It often uses an interdisciplinary approach combining the use of structural biology with advanced enzymological, spectroscopic or computational studies.