Sustainability database

Research

Rapid Evolution of Enzymes

Rapid Evolution of Enzymes and Synthetic Micro-organisms for the Development of Industrial Biocatalysts

The use of biocatalysts in the manufacture of chemicals presents significant advantages in terms of enhanced reaction selectivity, reduced cost of raw materials, lower energy costs, safety and importantly sustainability.

http://www.bbsrc.ac.uk/pa/grants/AwardDetails.aspx?FundingReference=BB/K...

Budget: 
£3,604,052.00
Project date: 
Saturday, December 1, 2012 to Thursday, November 30, 2017

Connections

Person

Prof Nigel Scrutton

Enzyme catalysts are central to life. They are the vehicles for delivering innovative bioscience solutions to chemicals manufacture, drug discovery, therapeutics and bioprocessing. They are the key enablers in the white biotechnology revolution, providing essential components in the new science of 'synthetic biology', offering new routes to biofuels, bulk and commodity chemicals and novel therapeutics.

Keywords: 
Quantum biology, Biology, Biocatalysis, Bioenergy, Renewable energy, Energy, Biotechnology

Person

Prof Jason Micklefield

The Micklefield lab is engaged in Chemical Biology and Synthetic Biology research tackling diverse challenges at the Chemistry-Biology interface utilising techniques and knowledge from organic and biological chemistry through to molecular microbiology and genetics. The main research themes include: 1) Nucleic acid redesign and recognition (including Riboswitches); 2) Biocatalysis and enzyme mechanism; 3) Biosynthesis and biosynthetic pathway engineering.

Keywords: 
Chemicals, Chemistry, Biology, Biotechnology, Genetics, Biocatalysis, Biosynthesis

Person

Prof Roy Goodacre

Roy Goodacre's research interests are broadly within analytical biotechnology and systems biology. He has over 18 years experience of advanced data analysis applied to spectroscopic, mass spectrometric and metabolomics data; over 18 years experience in mass spectrometry (MS), and over 11 years in vibrational spectroscopy.

Keywords: 
Biotechnology, Technology

Person

Prof Nicholas Turner

Other project: Sustainable Laboratories

Keywords: 
Bioenergy, Energy, Renewable energy, Biotechnology, Biology, Technology, Biocatalysis, Biotransformation, Chemistry, Sustainability, Teaching, Education

Person

Prof David Leys

The research in our group mainly uses x-ray crystallography and a range of other techniques to address how macromolecular structure determines function. We focus on several aspects: how do proteins interact with other macromolecules (RNA, DNA or other proteins) or their substrates?  How do enzymes work, particularly those for which mechanistic insight is lacking? Protein structures also form the basis of protein engineering and for structure-based drug design.

Keywords: 
Biology, Chemistry, Biochemistry, Health, Polymers

Person

Prof Sabine Flitsch

Research interests:

Glycosciences, Biocatalysis, Monooxygenases, Protein-Ligand Interactions

Keywords: 
Biocatalysis, Chemicals, Chemistry, Biology, Health, Food